KRT10/KRT13 monoclonal antibody, clone CK 208
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Specification
Product Description
Mouse monoclonal antibody raised against native KRT10/KRT13.
Immunogen
Native purified human KRT10/KRT13.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — KRT10
Entrez GeneID
3858Gene Name
KRT10
Gene Alias
CK10, K10, KPP
Gene Description
keratin 10
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq
Other Designations
cytokeratin 10
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Gene Info — KRT13
Entrez GeneID
3860Gene Name
KRT13
Gene Alias
CK13, K13, MGC161462, MGC3781
Gene Description
keratin 13
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq
Other Designations
cytokeratin 13|keratin, type I cytoskeletal 13
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Interactome
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Publication Reference
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Correlation of clinical, histological, and cytokeratin profiles of squamous cell carcinoma of the oral tongue with prognosis.
Silveira EJ, Godoy GP, Lins RD, Arruda Mde L, Ramos CC, Freitas Rde A, Queiroz LM.
International Journal of Surgical Pathology 2007 Oct; 15(4):376.
Application:IHC-P, Human, Human squamousc cell carcinoma of the oral tongue.
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Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis.
Ivanyi D, Groeneveld E, Van Doornewaard G, Mooi WJ, Hageman PC.
Cancer Research 1990 Aug; 50(16):5143.
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The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.
Moll R, Franke WW, Schiller DL, Geiger B, Krepler R.
Cell 1982 Nov; 31(1):11.
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Correlation of clinical, histological, and cytokeratin profiles of squamous cell carcinoma of the oral tongue with prognosis.
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