B3GAT1 monoclonal antibody, clone NK-1 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native B3GAT1.
Immunogen
Native purified from human peripheral blood mononuclear cells.
Host
Mouse
Reactivity
Human
Specificity
Specificity human CD57
Form
Liquid
Conjugation
Biotin
Isotype
IgM
Recommend Usage
Flow Cytometry (10 ul/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — B3GAT1
Entrez GeneID
27087Gene Name
B3GAT1
Gene Alias
CD57, GLCATP, GlcAT-P, GlcUAT-P, HNK-1, HNK1, LEU7, NK-1
Gene Description
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
Omim ID
151290Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
CD57 antigen|LEU7 antigen|UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase|beta-1,3-glucuronyltransferase 1|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1|glucuronosyltransferase P
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Interactome
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Pathway
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Publication Reference
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CD57+ T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses.
d'Angeac AD, Monier S, Pilling D, Travaglio-Encinoza A, Reme T, Salmon M.
European Journal of Immunology 1994 Jul; 24(7):1503.
Application：Flow Cyt, Human, PBMCs.
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Characterization of HNK-1+ (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability.
Abo T, Cooper MD, Balch CM.
Journal of Immunology 1982 Oct; 129(4):1752.
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A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
Abo T, Balch CM.
Journal of Immunology 1981 Sep; 127(3):1024.
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CD57+ T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses.
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