SPN monoclonal antibody, clone DF-T1 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native SPN.
Immunogen
Native purified from myeloblastic KG1 Cells.
Host
Mouse
Reactivity
Human
Specificity
Specificity human CD43
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Flow Cytometry
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Gene Info — SPN
Entrez GeneID
6693Gene Name
SPN
Gene Alias
CD43, GPL115, LSN
Gene Description
sialophorin
Omim ID
182160Gene Ontology
HyperlinkGene Summary
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[supplied by OMIM
Other Designations
leukosialin|sialophorin (gpL115, leukosialin, CD43)|sialophorin (leukosialin, CD43)
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Interactome
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Pathway
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Disease
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Publication Reference
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Negative regulation of T-cell adhesion and activation by CD43.
Manjunath N, Correa M, Ardman M, Ardman B.
Nature 1995 Oct; 377(6549):535.
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The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation.
Cyster JG, Shotton DM, Williams AF.
The EMBO Journal 1991 Apr; 10(4):893.
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Negative regulation of T-cell adhesion and activation by CD43.
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