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CD3 monoclonal antibody, clone UCHT1 (Biotin)

  • Catalog # : MAB6004
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD3.
  • Immunogen:
  • Native purified from human thymocytes and peripheral blood lymphocytes from a patient with Sezary cell leukemia.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Specificity ε chain of the CD3/T cell antigen receptor complex
  • Form:
  • Liquid
  • Conjugation:
  • Biotin
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (10 ul/106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 915
  • Gene Name:
  • CD3D
  • Gene Alias:
  • CD3-DELTA,T3D
  • Gene Description:
  • CD3d molecule, delta (CD3-TCR complex)
  • Gene Summary:
  • The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq
  • Other Designations:
  • CD3D antigen, delta polypeptide,CD3d antigen, delta polypeptide (TiT3 complex),T-cell receptor T3 delta chain,T-cell surface glycoprotein CD3 delta chain
  • Gene Information
  • Entrez GeneID:
  • 916
  • Gene Name:
  • CD3E
  • Gene Alias:
  • FLJ18683,T3E,TCRE
  • Gene Description:
  • CD3e molecule, epsilon (CD3-TCR complex)
  • Gene Summary:
  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq
  • Other Designations:
  • CD3-epsilon,CD3E antigen, epsilon polypeptide,CD3e antigen, epsilon polypeptide (TiT3 complex),T-cell antigen receptor complex, epsilon subunit of T3,T-cell surface antigen T3/Leu-4 epsilon chain,T-cell surface glycoprotein CD3 epsilon chain
  • Gene Information
  • Entrez GeneID:
  • 917
  • Gene Name:
  • CD3G
  • Gene Alias:
  • CD3-GAMMA,FLJ17620,FLJ17664,FLJ79544,FLJ94613,MGC138597,T3G
  • Gene Description:
  • CD3g molecule, gamma (CD3-TCR complex)
  • Gene Summary:
  • The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq
  • Other Designations:
  • CD3G antigen, gamma polypeptide,CD3g antigen, gamma polypeptide (TiT3 complex),T-cell antigen receptor complex, gamma subunit of T3,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain
  • Gene Information
  • Entrez GeneID:
  • 919
  • Gene Name:
  • CD247
  • Gene Alias:
  • CD3-ZETA,CD3H,CD3Q,CD3Z,T3Z,TCRZ
  • Gene Description:
  • CD247 molecule
  • Gene Summary:
  • The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD247 antigen, zeta subunit,CD3Z antigen, zeta polypeptide (TiT3 complex),OTTHUMP00000032544,T-cell antigen receptor complex, zeta subunit of CD3,T-cell receptor T3 zeta chain,T-cell receptor zeta chain,T-cell surface glycoprotein CD3 zeta chain
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