MMP1 monoclonal antibody, clone SB12e (HRP)
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MMP1.
Immunogen
Recombinant protein corresponding to human MMP1.
Host
Mouse
Reactivity
Human
Specificity
human MMP-1; Does not cross react to human MMP-2, MMP-3 or MMP-9.
Form
Liquid
Conjugation
HRP
Concentration
Lot specific
Isotype
IgG2b
Recommend Usage
ELISA (1:1000-1:4000)
Immunohistochemistry (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP1
Entrez GeneID
4312Gene Name
MMP1
Gene Alias
CLG, CLGN
Gene Description
matrix metallopeptidase 1 (interstitial collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Other Designations
fibroblast collagenase|interstitial collagenase|matrix metalloprotease 1|matrix metalloproteinase 1|matrix metalloproteinase 1 (interstitial collagenase)
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Interactome
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Pathway
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Disease
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Publication Reference
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Matrix metalloproteinases degrade myelin basic protein.
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E.
Neuroscience Letters 1995 Dec; 201(3):223.
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Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation.
Thrailkill KM, Quarles LD, Nagase H, Suzuki K, Serra DM, Fowlkes JL.
Endocrinology 1995 Aug; 136(8):3527.
Application:IP, Mouse, MC3T3-E1 cells.
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Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.
Fowlkes JL, Enghild JJ, Suzuki K, Nagase H.
The Journal of Biological Chemistry 1994 Oct; 269(41):25742.
Application:WB, Human, Fibroblast-conditioned medium.
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Matrix metalloproteinases degrade myelin basic protein.
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