ZAP70 monoclonal antibody, clone SBZAP (AP)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant ZAP70.
Immunogen
Recombinant protein corresponding to amino acids 280-309 of human ZAP70.
Host
Mouse
Reactivity
Human
Specificity
human TCR ζ; Zap-70 (Mr 70 KDa).
Form
Liquid
Conjugation
AP
Concentration
Lot specific
Isotype
IgG1, kappa
Recommend Usage
ELISA (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris, pH 8.0 (1mM MgCl2, 50% glycerol, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — ZAP70
Entrez GeneID
7535Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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Publication Reference
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The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
van Oers NS, Weiss A.
Seminars in Immunology 1995 Aug; 7(4):227.
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F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling.
Wange RL, Isakov N, Burke TR Jr, Otaka A, Roller PP, Watts JD, Aebersold R, Samelson LE.
The Journal of Biological Chemistry 1995 Jan; 270(2):944.
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The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
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