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Last updated: 2016/10/23
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PSEN1 monoclonal antibody, clone APS11

  • Catalog # : MAB5677
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of PSEN1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 21-34 of human PSEN1.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Lyophilized
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS
  • Storage Instruction:
  • Store at 4°C or -20°C on dry atmosphere.
    After reconstitution with water and glycerol (1:1), store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 5663
  • Gene Name:
  • PSEN1
  • Gene Alias:
  • AD3,FAD,PS1,S182
  • Gene Description:
  • presenilin 1
  • Gene Summary:
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq
  • Other Designations:
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