Asgr1 monoclonal antibody, clone 8D7
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Specification
Product Description
Mouse monoclonal antibody raised against native Asgr1.
Immunogen
Native purified rat liver membrane extracts Asgr1.
Host
Mouse
Reactivity
Human, Rat
Specificity
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 KDa) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediates the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
Form
Liquid
Isotype
IgG1
Recommend Usage
Recommend dilution at 1:10
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% BSA, 0.02% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — Asgr1
Entrez GeneID
24210Gene Name
Asgr1
Gene Alias
ASGR, MGC108731, RATRHL1, RHL1
Gene Description
asialoglycoprotein receptor 1
Gene Ontology
HyperlinkGene Summary
RHL1
Other Designations
Asialoglycoprotein receptor 1 (hepatic lectin)|asialoglycoprotein receptor (RHL1)|asialoglycoprotein receptor 1 (hepatic lectin)|hepatic lectin 1 RHL1|hepatic lectin 1, RHL1
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Publication Reference
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A monoclonal antibody to rat asialoglycoprotein receptor that recognizes an epitope specific to its major subunit.
Shimada M, Mizuno M, Uesu T, Nasu J, Okada H, Shimomura H, Yamamoto K, Tsuji T, Shiratori Y.
Hepatology Research: the Official Journal of the Japan Society of Hepatology 2003 May; 26(1):55.
Application：Flow Cyt, IF, WB, Human, COS-1 cells.
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Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma.
Hyodo I, Mizuno M, Yamada G, Tsuji T.
Liver 1993 Apr; 13(2):80.
Application：IHC, Human, Liver.
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Monoclonal antibodies identifying antigens on distinct domains of rat hepatocytes.
Mizuno M, Yamada G, Sugiyama T, Vierling JM, Brown WR.
Liver 1987 Oct; 7(5):251.
Application：IHC, WB-Ti, Rat, Liver.
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A monoclonal antibody to rat asialoglycoprotein receptor that recognizes an epitope specific to its major subunit.
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