Immunized with human CGB, conjugated to various carrier proteins.
5H4-E2 is specific to the Beta chain of hCG. Since the Beta chain levels rise faster in urine, This antibody will detect hCG in urine as early as 1-3 days after successful (artificial) conception as opposed to alpha or dimer specific antibodies. In hCG producing tumors such as certain chorial, testicular, embyionic and lung carcinomas, theBeta chain is also produced in higher quantaties than the alpha or dimeric chains.
The optimal working dilution should be determined by the end user.
In PBS (0.05% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq