KRT8 monoclonal antibody, clone SB37b
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More Files
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Immunofluorescence
Cell Cytospin of the HCC38 breast carcinoma cell line was incubated with KRT8 monoclonal antibody, clone SB37b (Cat # MAB5629). Positive cells were viewed by fluorescence microscopy.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant KRT8.
Immunogen
Recombinant protein corresponding to C-terminus of human KRT8.
Host
Mouse
Reactivity
Human
Specificity
Cytokeratin 8.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (10 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunofluorescence
Cell Cytospin of the HCC38 breast carcinoma cell line was incubated with KRT8 monoclonal antibody, clone SB37b (Cat # MAB5629). Positive cells were viewed by fluorescence microscopy.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KRT8
Entrez GeneID
3856Gene Name
KRT8
Gene Alias
CARD2, CK8, CYK8, K2C8, K8, KO
Gene Description
keratin 8
Gene Ontology
HyperlinkGene Summary
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
Other Designations
cytokeratin 8|keratin, type II cytoskeletal 8
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Interactome
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Disease
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Publication Reference
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The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins.
Hanukoglu I, Fuchs E.
cell 1983 Jul; 33(3):915.
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Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies.
S C Tseng, M J Jarvinen, W G Nelson, J W Huang, J Woodcock-Mitchell, T T Sun.
Cell 1982 Sep; 30(2):361.
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A subfamily of relatively large and basic cytokeratin polypeptides as defined by peptide mapping is represented by one or several polypeptides in epithelial cells.
Schiller DL, Franke WW, Geiger B.
The EMBO Journal 1982 Jan; 1(6):761.
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The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins.
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