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CD8A/CD8B monoclonal antibody, clone RFT-8

  • Catalog # : MAB5618
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD8A/CD8B.
  • Immunogen:
  • Native purified CD8A/CD8B from human thymocytes and E-rosetted lymphocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • human CD8.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (1 ug/106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 100 mM BBS, pH 8.2
  • Storage Instruction:
  • Store at 4°C.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 925
  • Gene Name:
  • CD8A
  • Gene Alias:
  • CD8,Leu2,MAL,p32
  • Gene Description:
  • CD8a molecule
  • Gene Summary:
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD8 antigen alpha polypeptide,CD8 antigen, alpha polypeptide (p32),Leu2 T-lymphocyte antigen,OKT8 T-cell antigen,T cell co-receptor,T-cell antigen Leu2,T-cell surface glycoprotein CD8 alpha chain,T-lymphocyte differentiation antigen T8/Leu-2,T8 T-cell ant
  • Gene Information
  • Entrez GeneID:
  • 926
  • Gene Name:
  • CD8B
  • Gene Alias:
  • CD8B1,LYT3,Leu2,Ly3,MGC119115
  • Gene Description:
  • CD8b molecule
  • Gene Summary:
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq
  • Other Designations:
  • CD8 antigen, beta polypeptide (p37),CD8 antigen, beta polypeptide 1 (p37),CD8b antigen,OTTHUMP00000160761,T lymphocyte surface glycoprotein beta chain,T-cell surface glycoprotein CD8 beta chain
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