COL1A2 monoclonal antibody, clone 2A3
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Specification
Product Description
Mouse monoclonal antibody raised against native COL1A2.
Immunogen
Native human COL1A2.
Host
Mouse
Reactivity
Human
Specificity
Reacts with human Type I collagen.
Form
Liquid
Isotype
IgG2b
Recommend Usage
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
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Gene Info — COL1A2
Entrez GeneID
1278Gene Name
COL1A2
Gene Alias
OI4
Gene Description
collagen, type I, alpha 2
Gene Ontology
HyperlinkGene Summary
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
Other Designations
alpha 2 type I collagen|alpha 2(I)-collagen|alpha-2 collagen type I|collagen I, alpha-2 polypeptide|collagen of skin, tendon and bone, alpha-2 chain|type I procollagen
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Interactome
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Pathway
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Disease
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