TRIM5 monoclonal antibody, clone 3B11H2
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551) against lysate of human breast tissue with Pierce's SuperSignal Femto substrate.
Western Blot (Recombinant protein)
Western blot analysis using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551) against truncated TRIM5 recombinant protein.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded metastatic adenocarcinoma (A) showing cytoplasmic localization, human stomach adenocarcinoma (B) showing cytoplasmic localization, using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551).
The second antibody HRP was used brfore color development with AEC (A) and DAB (B).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TRIM5.
Immunogen
Recombinant protein corresponding to human TRIM5.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:1000-1:5000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:400)
Immunohistochemistry (Frozen sections) (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551) against lysate of human breast tissue with Pierce's SuperSignal Femto substrate.Western Blot (Recombinant protein)
Western blot analysis using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551) against truncated TRIM5 recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded metastatic adenocarcinoma (A) showing cytoplasmic localization, human stomach adenocarcinoma (B) showing cytoplasmic localization, using TRIM5 monoclonal antibody, clone 3B11H2 (Cat # MAB5551).
The second antibody HRP was used brfore color development with AEC (A) and DAB (B).Immunohistochemistry (Frozen sections)
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Gene Info — TRIM5
Entrez GeneID
85363Gene Name
TRIM5
Gene Alias
RNF88, TRIM5alpha
Gene Description
tripartite motif-containing 5
Omim ID
608487Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Five alternatively spliced transcript variants for this gene have been described. However, the full length nature of two of the variants has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000069811|OTTHUMP00000069812|tripartite motif protein TRIM|tripartite motif protein TRIM5|tripartite motif-containing protein 5 alpha
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Interactome
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Disease
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Publication Reference
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Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.
Song B, Javanbakht H, Perron M, Park DH, Stremlau M, Sodroski J.
Journal of Virology 2005 Apr; 79(7):3930.
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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J.
Nature 2004 Feb; 427(6977):848.
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Retrovirus restriction by TRIM5alpha variants from Old World and New World primates.
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