MSH2 monoclonal antibody, clone 3A2B8C
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MSH2.
Immunogen
Recombinant protein corresponding to human MSH2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:200-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
Immunohistochemistry (Frozen sections) (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using MSH2 monoclonal antibody, clone 3A2B8C (Cat # MAB5538) against A-431 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human rectum carcinoma tissue, showing nuclear and cytoplasmic localization using MSH2 monoclonal antibody, clone 3A2B8C (Cat # MAB5538) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MSH2
Entrez GeneID
4436Gene Name
MSH2
Gene Alias
COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Gene Description
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Gene Ontology
HyperlinkGene Summary
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq
Other Designations
mutS homolog 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Mutation of a mutL homolog in hereditary colon cancer.
Papadopoulos N, Nicolaides NC, Wei YF, Ruben SM, Carter KC, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, et al..
Science 1994 Mar; 263(5153):1625.
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Mismatch repair and cancer.
Palombo F, Hughes M, Jiricny J, Truong O, Hsuan J.
Nature 1994 Feb; 367(6462):417.
Application:IHC, WB-Ti, Human, Human hereditary nonpolyposis colorectal carcinoma.
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Mutation of a mutL homolog in hereditary colon cancer.
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