MCL1 monoclonal antibody, clone 8C6D4B1
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MCL1.
Immunogen
Recombinant protein corresponding to human MCL1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:200-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:1000)
Immunohistochemistry (Frozen sections) (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using MCL1 monoclonal antibody, clone 8C6D4B1 (Cat # MAB5535) against BCBL-1 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lymph node tissue showing cytoplasmic localization using MCL1 monoclonal antibody, clone 8C6D4B1 (Cat # MAB5535) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MCL1
Entrez GeneID
4170Gene Name
MCL1
Gene Alias
BCL2L3, EAT, MCL1L, MCL1S, MGC104264, MGC1839, TM
Gene Description
myeloid cell leukemia sequence 1 (BCL2-related)
Omim ID
159552Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. [provided by RefSeq
Other Designations
OTTHUMP00000032794|OTTHUMP00000032795|induced myeloid leukemia cell differentiation protein Mcl-1|myeloid cell leukemia sequence 1|myeloid cell leukemia sequence 1, isoform 1
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Interactome
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Disease
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