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Last updated: 2017/7/23
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ANPEP monoclonal antibody, clone 22A5 (Biotin)

  • Catalog # : MAB5509
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ANPEP.
  • Immunogen:
  • Native purified ANPEP from osteoclastomas.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes the (Mr 150-170KDa) cell surface glycoprotein expressed in a pan-myeloid fashion. This antibody also reacts with osteoclasts in giant cell tumors of bone (osteoclastoma), clear cell chondrosarcoma and aneurysmal bone cysts. The CD13 antigen is present on most cells of myeloid origin, including granulocytes and monocytes in normal peripheral blood. CD13 is not expressed on B-cells, T-cells, platelets or erythrocytes. Expression of this antigen is greater on monocytes than on granulocytes.
  • Form:
  • Liquid
  • Conjugation:
  • Biotin
  • Isotype:
  • IgG
  • Recommend Usage:
  • Flow Cytometry (using 1ug to stain 1 x 106 cells)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, 2 mM EDTA, pH 7.2 (1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 290
  • Gene Name:
  • ANPEP
  • Gene Alias:
  • APN,CD13,LAP1,PEPN,gp150,p150
  • Gene Description:
  • alanyl (membrane) aminopeptidase
  • Gene Summary:
  • Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000194690,aminopeptidase M,aminopeptidase N,membrane alanine aminopeptidase,microsomal aminopeptidase
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