Mouse monoclonal antibody raised against native ITGA2B.
Native purified ITGA2B from human washed platelets.
The CD41 antigen (platelet GPIIb; alpha IIb integrin) is a glycoprotein composed of 2 chains, GPIIb alpha (120 KDa) and GPIIb beta (23KDa), linked by one disulfide bond. CD41 is always non-covalently associated with CD61 (platelet GPIIIa, beta 3 integrin), to form the GPIIb-IIIa (CD41/CD61) complex. CD41 is expressed by platelets, megakaryocytes and by a small subset of CD34+ cells suggesting that CD41/CD61 is the earliest marker of the megakaryocytic lineage. Clone SZ.22 reacts with the alpha chain of CD41. It has been assigned to the CD41 cluster of differentiation at the 5th International Workshop on human Leucocyte Differentiation Antigens in Boston, in 1993.
Immunohistochemistry (Frozen sections) (1:50-1:100) Immunocytochemistry (1:50-1:100) Immunofluorescence (20ul/106 platelets/test) Flow Cytometry (20ul/106 platelets/test) The optimal working dilution should be determined by the end user.
In PBS (2 mg/mL BSA, 0.09% sodium azide)
Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK