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Last updated: 2016/11/27
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ITGA2B monoclonal antibody, clone P2 (FITC)

  • Catalog # : MAB5494
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGA2B.
  • Immunogen:
  • Native purified ITGA2B from human platelets.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • The molecular weight of the recognized antigen is 135-95KDa. Reacts with gpIIb in the intact complex with gpIIIa, but not with gpIIb or gpIIIa, separately. Inhibits platelet aggregation induced by thrombin, collagen and ADP.
  • Form:
  • Liquid
  • Conjugation:
  • FITC
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20ul/5 x 105 platelets/test)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (2 mg/mL BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Flow Cytometry
  • Application Image
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3674
  • Gene Name:
  • ITGA2B
  • Gene Alias:
  • CD41,CD41B,GP2B,GPIIb,GTA,HPA3
  • Gene Description:
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Gene Summary:
  • ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
  • Other Designations:
  • integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK
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