Mouse monoclonal antibody raised against native ITGAM.
Native purified ITGAM from human monocytes.
CD11b antigen is referred to under several names i.e.: alpha-M integrin chain, Mac-1, CR3, iC3bR, or Mo1. It is a type I integral transmembrane glycoprotein of 170/165KDa under reducing/non-reducing conditions, respectively. CD11b shows 19 potential N-glycosylation sites. Bear1 monoclonal antibody was assigned to the CD11b cluster of differentiation during the 6th International Workshop on HLDA Typing in Kobe, Japan (1996).
The optimal working dilution should be determined by the end user.
In PBS (2 mg/mL BSA, 0.09% sodium azide)
Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq