This antibody represents an excellent marker to distinguish myoepithelial cells from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and benign from malignant forms of e.g. mammary gland tumors. Most malignant forms of mammary tumors are negative for cytokeratin 17 (Mr 46,000).
Immunohistochemistry (1:10) The optimal working dilution should be determined by the end user.
Lyophilized from PBS
Store at 4°C on dry atmosphere. After reconstitution with sterile distilled water, store at 4°C.
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq