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Last updated: 2017/10/22
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MPO monoclonal antibody, clone 2C7

  • Catalog # : MAB5342
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against MPO.
  • Immunogen:
  • Human MPO.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human myeloperoxidase (MPO). MPO is an important component of azurophilic granules in neutrophils, being involved in microbicidal processes. The protein is a multimer of 2 heavy chains (55kD) and two light chains (15kD), the heavy chains being linked by a disulphide bond. MON 8074 recognizes native MPO in Western blots, and the heavy chain following boiling of the sample. This antibody also recognizes recombinant MPO in Western blots and weakly in ELISA. This antibody may be of value in the study of myeloid cells and myeloid leukaemias by flow cytometry following cell permeablisation.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Frozen sections) (1:1000-1: 5000)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
    Flow Cytometry (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry staining of MPO in human bone marrow (formalin-fixed paraffin-embedded) using MPO monoclonal antibody, clone 2C7 (Cat. # MAB5342).
  • Immunohistochemistry (Frozen sections)
  • ELISA
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • ELISA
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 4353
  • Gene Name:
  • MPO
  • Gene Alias:
  • -
  • Gene Description:
  • myeloperoxidase
  • Gene Summary:
  • Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq
  • Other Designations:
  • -
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