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Last updated: 2017/5/21
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CCND3 monoclonal antibody, clone DCS-22

  • Catalog # : MAB5332
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant CCND3.
  • Immunogen:
  • Recombinant protein corresponding to human CCND3.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes the 34kD cyclin D3. Cyclin D3 is expressed in the G1 phase of the cell cycle, but after cyclin D1.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:40)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In tissue culture supernatant (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical staining of human breast carcinoma with CCND3 monoclonal antibody, clone DCS-22 (Cat # MAB5332).
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 896
  • Gene Name:
  • CCND3
  • Gene Alias:
  • -
  • Gene Description:
  • cyclin D3
  • Gene Summary:
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • D3-type cyclin,G1/S-specific cyclin D3,OTTHUMP00000016390
  • Interactome
  • Interactome
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