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Last updated: 2017/7/16
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SELPLG monoclonal antibody, clone 3E2.25.5

  • Catalog # : MAB5327
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native SELPLG.
  • Immunogen:
  • Native purified SELPLG from human neutrophils.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes the human CD162 cell surface glycoprotein, a 120kD molecule also known as P-Selectin Glycoprotein Ligand I (PSGL-1). CD162 is the major counter receptor for P-selectin and is involved in neutrophil attachment and rolling to endothelium. In peripheral blood CD162 is expressed by monocytes, granulocytes, T cells and some B cells. This antibody is a blocking antibody, inhibiting PSGL-1 and P-selectin interaction.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Functional Study
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 6404
  • Gene Name:
  • SELPLG
  • Gene Alias:
  • CD162,CLA,PSGL-1,PSGL1
  • Gene Description:
  • selectin P ligand
  • Gene Summary:
  • SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. [provided by RefSeq
  • Other Designations:
  • cutaneous lymphocyte-associated associated antigen
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