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Last updated: 2016/10/23
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ABCG2 monoclonal antibody, clone BXP-34

  • Catalog # : MAB5285
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ABCG2.
  • Immunogen:
  • Native purified ABCG2 from the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • BXP-34 reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in multidrug resistance. BXP-34 did not cross-react with the human MDR1, MRP1, MRP2, MRP5 gene products.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunocytochemistry (1:20-1:50)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In tissue culture supernatant (1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 9429
  • Gene Name:
  • ABCG2
  • Gene Alias:
  • ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,MGC102821,MRX,MXR,MXR1
  • Gene Description:
  • ATP-binding cassette, sub-family G (WHITE), member 2
  • Gene Summary:
  • The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq
  • Other Designations:
  • ABC transporter,ATP-binding cassette transporter G2,ATP-binding cassette, sub-family G, member 2,breast cancer resistance protein,mitoxantrone resistance protein,placenta specific MDR protein
  • Gene Pathway
  • Related Disease
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