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Last updated: 2016/11/27
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CD226 monoclonal antibody, clone DX11

  • Catalog # : MAB5270
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD226.
  • Immunogen:
  • Native purified CD226 from human cytotoxic T lymphocyte clone.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibdoy recognizes human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (3).
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (10ul of the suggested working dilution (1:25-1:100) to label 1x 106 cells in 100ul)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Gene Name:
  • CD226
  • Gene Alias:
  • DNAM-1,DNAM1,PTA1,TLiSA1
  • Gene Description:
  • CD226 molecule
  • Gene Summary:
  • This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq
  • Other Designations:
  • CD226 antigen,DNAX accessory molecule-1,T lineage-specific activation antigen 1 antigen,adhesion glycoprotein,platelet and T cell activation antigen 1
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