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Last updated: 2017/12/17
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ITGA5 monoclonal antibody, clone CLB-705

  • Catalog # : MAB5267
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGA5.
  • Immunogen:
  • Native purified from U937 cell line.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • The monoclonal antibody is directed against the CD49e-antigen, molecular weights: 17, 130 kD, (GP Ic or VLA-5 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP IIa or VLA beta-chain), resulting in the VLA-5 (alpha-5, beta-1) complex which is expressed on human platelets. Platelet VLA-5 functions as a fibronectin receptor and platelet adhesion to fibronectin is inhibited by this antibody. The monoclonal antibody reacts with platelets and monocytes. It reacts weakly with T-cells and granulocytes and with various cell types of non-hemopoietic origin.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM Tris, 150 mM NaCl, pH 8.0 (10 mg BSA, 0.001% thimerosal)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3678
  • Gene Name:
  • ITGA5
  • Gene Alias:
  • CD49e,FNRA,VLA5A
  • Gene Description:
  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
  • Gene Summary:
  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
  • Other Designations:
  • fibronectin receptor, alpha subunit,integrin alpha 5,very late activation protein 5, alpha subunit
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