Mouse monoclonal antibody raised against native ITGA5.
Native purified from U937 cell line.
The monoclonal antibody is directed against the CD49e-antigen, molecular weights: 17, 130 kD, (GP Ic or VLA-5 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP IIa or VLA beta-chain), resulting in the VLA-5 (alpha-5, beta-1) complex which is expressed on human platelets. Platelet VLA-5 functions as a fibronectin receptor and platelet adhesion to fibronectin is inhibited by this antibody. The monoclonal antibody reacts with platelets and monocytes. It reacts weakly with T-cells and granulocytes and with various cell types of non-hemopoietic origin.
The optimal working dilution should be determined by the end user.
In 20 mM Tris, 150 mM NaCl, pH 8.0 (10 mg BSA, 0.001% thimerosal)
Store at 4°C.
This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
fibronectin receptor, alpha subunit,integrin alpha 5,very late activation protein 5, alpha subunit