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Last updated: 2017/3/26
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CD180 monoclonal antibody, clone MHR73

  • Catalog # : MAB5256
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native CD180.
  • Immunogen:
  • Native purified CD180 from M12HRP cell line.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human CD180 (RP105) a 105kD type 1 transmembrane protein, which belongs to the toll-like receptor family. CD180 is primarily expressed in mature peripheral B cells and is thought to play a role in the innate immune response to bacterial lipopolysaccharide, through co-operation with MD-1 and TLR4. Cross linking of CD180 with clone MHR73 has been reported to induce resistance against irradiation induced apoptosis, B-cell proliferation and up-regulation of a co-stimulatory molecule CD80.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (10ul of the suggested working dilution (1:50-1:100) to label 106 cells in 100ul)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 4064
  • Gene Name:
  • CD180
  • Gene Alias:
  • LY64,Ly78,MGC126233,MGC126234,RP105
  • Gene Description:
  • CD180 molecule
  • Gene Summary:
  • CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq
  • Other Designations:
  • CD180 antigen,lymphocyte antigen-64, radioprotective, 105kDa
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