ITGB4 monoclonal antibody, clone 450-9D
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB4.
Immunogen
Native purified human ITGB4.
Host
Mouse
Reactivity
Human
Specificity
450-9D recognizes the human beta4 integrin (also known as CD104), a 205kD glycoprotein which associates with the alpha6 integrin to form the alpha6/beta4 complex. CD104 is expressed on epithelial cells, Schwann cells and various tumour cell lines. 450-9D recognizes an extracellular epitope on the CD104 molecule.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (10ul of the suggested working dilution (1:25-1:100) to label 106 cells in 100ul)
Immunohistochemistry (Frozen sections) (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ITGB4
Entrez GeneID
3691Gene Name
ITGB4
Gene Alias
CD104
Gene Description
integrin, beta 4
Gene Ontology
HyperlinkGene Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD104 antigen|GP150|integrin beta 4|integrin beta-4 subunit
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Interactome
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Pathway
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Disease
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