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Last updated: 2017/10/15
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ITGB4 monoclonal antibody, clone 450-9D

  • Catalog # : MAB5239
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGB4.
  • Immunogen:
  • Native purified human ITGB4.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • 450-9D recognizes the human beta4 integrin (also known as CD104), a 205kD glycoprotein which associates with the alpha6 integrin to form the alpha6/beta4 complex. CD104 is expressed on epithelial cells, Schwann cells and various tumour cell lines. 450-9D recognizes an extracellular epitope on the CD104 molecule.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (10ul of the suggested working dilution (1:25-1:100) to label 106 cells in 100ul)
    Immunohistochemistry (Frozen sections) (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3691
  • Gene Name:
  • ITGB4
  • Gene Alias:
  • CD104
  • Gene Description:
  • integrin, beta 4
  • Gene Summary:
  • Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD104 antigen,GP150,integrin beta 4,integrin beta-4 subunit
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