Mouse monoclonal antibody raised against recombinant TNFRSF8.
Recombinant protein corresponding to human TNFRSF8.
This antibody recognizes the human CD30 cell surface antigen, a 120kD glycoprotein. CD30 is expressed by some activated T lymphocytes, and also by Reed Sternberg cells of Hodgkin's disease and in cases of anaplastic large cell lymphoma.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:40) The optimal working dilution should be determined by the end user.
Lyophilized from tissue culture supernatant (0.09% sodium azide)
Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq