Mouse monoclonal antibody raised against synthetic peptide of KRT2.
A synthetic peptide corresponding to amino acids 2-23 of human KRT2.
Bovine, Human, Mouse, Rat
This antibody represents an excellent marker to study terminal epidermal differentiation. It is reactive with epidermal cells in uppermost suprabasal layers including scalp, foot and sole. It recognizes individual cells within epidermis of tongue and mamille (co-localization with cytokeratin 10). It is also reactive on hyperkeratosis of diverse viral and genetic origin. This antibody does not react with palate cytokeratin 2p. Antigen recognized in species: human, bovine (calf hoof epidermis, snooze epithelium; negative with tongue epithelium), mouse/rat (heterogeneously on foot sole epidermis only; negative with epidermis of other body sites).
Immunohistochemistry (1:20) The optimal working dilution should be determined by the end user.
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq