Mouse monoclonal antibody raised against native ABCC1.
Native human small cell lung cancer cell line H69AR.
Human, Monkey, Mouse, Rat
QCRL-4 reacts with a conformation-dependent internal epitope of MRP1, a 190 KDa trans-membrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines. QCRL-4 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles and its epitope has been localized to the second nucleotide binding domain of MRP1 between amino acids 1294 and 1531. QCRL-4 does not cross-react with human MDR1 and MDR3 gene products.
Flow Cytometry (1:20-1:40) Dot Blot (1:10000) The optimal working dilution should be determined by the end user.
In PBS (0.7% BSA, 0.09% sodium azide)
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq
ATP-binding cassette, sub-family C, member 1,LTC4 transporter,OTTHUMP00000045904,leukotriene C(4) transporter,multidrug resistance protein,multiple drug resistance protein 1,multiple drug resistance-associated protein