Mouse monoclonal antibody raised against recombinant ABCC1.
Recombinant protein corresponding to amino acids 617-932 of ABCC1.
QCRL-3 reacts with a conformation-dependent internal epitope of MRP1. It does not cross-react with human MDR1 and MDR3 gene products nor with murine MRP1. Cross reacts with monkey, but does not cross react with mouse or rat.
Flow Cytometry (1:20-1:50) The optimal working dilution should be determined by the end user.
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq
ATP-binding cassette, sub-family C, member 1,LTC4 transporter,OTTHUMP00000045904,leukotriene C(4) transporter,multidrug resistance protein,multiple drug resistance protein 1,multiple drug resistance-associated protein