CD28 monoclonal antibody, clone CD28.2 (PerCP)
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Specification
Product Description
Mouse monoclonal antibody raised against CD28.
Immunogen
Native from DC28.1.3.3 hybridoma cells.
Host
Mouse
Reactivity
Human, Primates
Specificity
This antibody reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of MW 44 KDa) which is a critical costimulatory receptor of T cells.
Form
Liquid
Conjugation
PerCP
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD28
Entrez GeneID
940Gene Name
CD28
Gene Alias
MGC138290, Tp44
Gene Description
CD28 molecule
Omim ID
186760Gene Ontology
HyperlinkGene Summary
CD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM
Other Designations
CD28 antigen|CD28 antigen (Tp44)|T-cell-specific surface glycoprotein
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Interactome
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Pathway
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Disease
- Acute Disease
- Arthritis
- Asthma
- Behcet Syndrome
- Bronchiolitis
- Carcinoma
- Celiac Disease
- Cholangitis
- Colon cancer
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Publication Reference
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Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates.
Jeong SH, Qiao M, Nascimbeni M, Hu Z, Rehermann B, Murthy K, Liang TJ.
Journal of Virology 2004 Jul; 78(13):6995.
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Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling.
Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D.
Molecular and Cellular Biology 2004 May; 24(9):3860.
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Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.
Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD.
Journal of Immunology 2001 Jan; 166(1):197.
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Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment.
Tazi A, Moreau J, Bergeron A, Dominique S, Hance AJ, Soler P.
Journal of Immunology 1999 Sep; 163(6):3511.
Application:IHC-Fr, Human, Human lung.
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Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells.
Galea-Lauri J, Darling D, Gan SU, Krivochtchapov L, Kuiper M, Gaken J, Souberbielle B, Farzaneh F.
Journal of Immunology 1999 Jul; 163(1):62.
Application:Flow Cyt, Func, Human, B cells, T cells.
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Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates.
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