TNFRSF8 monoclonal antibody, clone MEM-268 (PE)
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Specifications
Product Description
Mouse monoclonal antibody raised against TNFRSF8.
Immunogen
Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line).
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes extracellular part of CD30 (Ki-1 antigen), a 105 KDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells.
Form
Liquid
Conjugation
PE
Isotype
IgG
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — TNFRSF8
Entrez GeneID
943Gene Name
TNFRSF8
Gene Alias
CD30, D1S166E, KI-1
Gene Description
tumor necrosis factor receptor superfamily, member 8
Omim ID
153243Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CD30 antigen|CD30L receptor|Ki-1 antigen|OTTHUMP00000001783|cytokine receptor CD30|lymphocyte activation antigen CD30
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies.
Kusanovic JP, Romero R, Hassan SS, Gotsch F, Edwin S, Chaiworapongsa T, Erez O, Mittal P, Mazaki-Tovi S, Soto E, Than NG, Friel LA, Yoon BH, Espinoza J.
The Journal of Maternal-Fetal & Neonatal Medicine 2007 Dec; 20(12):867.
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CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.
Wright CW, Rumble JM, Duckett CS.
The Journal of Biological Chemistry 2007 Apr; 282(14):10252.
Application:Flow Cyt, Mouse, CHO cells.
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Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease.
Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS.
Blood 2007 Mar; 109(5):2225.
Application:Flow Cyt, Mouse, Mouse lymphocytes.
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Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies.
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