ICAM1 monoclonal antibody, clone 1H4 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native ICAM1.
Immunogen
Native purified ICAM1 from Raji cells and spleen cells fused with NS1 cells.
Host
Mouse
Theoretical MW (kDa)
85-110
Reactivity
Human
Specificity
This antibody reacts with CD54 (ICAM-1), a 85-110 KDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.
Form
Liquid
Conjugation
FITC
Isotype
IgG2b
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — ICAM1
Entrez GeneID
3383Gene Name
ICAM1
Gene Alias
BB2, CD54, P3.58
Gene Description
intercellular adhesion molecule 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq
Other Designations
cell surface glycoprotein P3.58|human rhinovirus receptor|intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites.
Williams DT, Chaudhry Y, Goodfellow IG, Lea S, Evans DJ.
The Journal of General Virology 2004 Mar; 85(Pt 3):731.
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Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus.
Ockenhouse CF, Betageri R, Springer TA, Staunton DE.
Cell 1992 Jan; 68(1):63.
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Adhesion receptors of the immune system.
Springer TA.
Nature 1990 Aug; 346(6283):425.
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Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites.
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