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Last updated: 2017/7/16
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GP1BA monoclonal antibody, clone HIP1 (PE)

  • Catalog # : MAB5073
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native GP1BA.
  • Immunogen:
  • Native purified GP1BA from peripheral blood mononuclear cells of a patient suffering with CLL.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Primates
  • Specificity:
  • This antibody reacts with CD42b (GPIb alpha), a 135-145 KDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 KDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.2% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Surface staining of human platelets with GP1BA monoclonal antibody, clone HIP1 (PE) (Cat # MAB5073).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 2811
  • Gene Name:
  • GP1BA
  • Gene Alias:
  • BSS,CD42B,CD42b-alpha,GP1B,MGC34595
  • Gene Description:
  • glycoprotein Ib (platelet), alpha polypeptide
  • Gene Summary:
  • Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
  • Other Designations:
  • platelet glycoprotein Ib alpha polypeptide,platelet membrane glycoprotein 1b-alpha subunit
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