IGF2R monoclonal antibody, clone MEM-238 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant IGF2R.
Immunogen
Recombinant protein corresponding to IGF2R.
Host
Mouse
Reactivity
Human, Primates
Specificity
This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 KDa multifunctional type I transmembrane protein.
Form
Liquid
Conjugation
APC
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — IGF2R
Entrez GeneID
3482Gene Name
IGF2R
Gene Alias
CD222, CIMPR, M6P-R, MPR1, MPRI
Gene Description
insulin-like growth factor 2 receptor
Omim ID
147280Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq
Other Designations
OTTHUMP00000017536|cation-independent mannose-6 phosphate receptor|insulin-like growth factor-2 receptor (mannose-6-phosphate receptor, cation-independent)
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Interactome
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Pathway
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Disease
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Publication Reference
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Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.
Wood RJ, Hulett MD.
The Journal of Biological Chemistry 2007 Dec; 283(7):4165.
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Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes.
Gasanov U, Koina C, Beagley KW, Aitken RJ, Hansbro PM.
Infection and Immunity 2006 Jan; 74(1):566.
Application:WB-Ce, Mouse, McCoy, MS9, MS9II cells.
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The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration.
Leksa V, Godar S, Cebecauer M, Hilgert I, Breuss J, Weidle UH, Horejsi V, Binder BR, Stockinger H.
The Journal of Biological Chemistry 2002 Oct; 277(43):40575.
Application:Flow Cyt, Mouse, Mouse fibroblasts.
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Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.
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