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Last updated: 2016/11/27
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SIRT1 monoclonal antibody

  • Catalog # : MAB4950
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of SIRT1.
  • Immunogen:
  • A synthetic peptide corresponding to human SIRT1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide, 0.05% proclin 300)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot was performed using nuclear extracts from HeLa cells (HeLa NE, 20 ug) and SIRT1 monoclonal antibody (Cat # MAB4950) at dilution 1 : 500 in TBS-Tween + 5% skimmed milk.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • SIRT1
  • Gene Alias:
  • SIR2L1
  • Gene Description:
  • sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
  • Gene Summary:
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000019691,OTTHUMP00000060745,SIR2alpha,sir2-like 1,sirtuin 1,sirtuin type 1
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