Mouse monoclonal antibody raised against synthetic peptide of LEP.
A synthetic cyclized peptide corresponding to amino acids 92-145 of human LEP.
human Leptin. Binds to the carboxyl terminal region of the protein and to the intact leptin specifically in ELISA and immunocytochemistry. Cross-reactivity: Leptin (human) 100% Leptin (92-145) cyclized 100% Epidermal Growth Factor (human) 0% Insulin (human) 0% Insulin-like Growth Factor 1 (human) 0% Insulin-like Growth Factor 2 (Rat) 0% Parathyroid hormone (human) 0% Transforming Growth Factor-alpha (human) 0%
Immunofluorescence (1:2000) The optimal working dilution should be determined by the end user.
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq