F12 monoclonal antibody, clone B3336M
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Specification
Product Description
Mouse monoclonal antibody raised against F12.
Immunogen
Purified human F12.
Host
Mouse
Reactivity
Human
Specificity
Reacts with the light chain of human Factor XII and at 100 nM inhibits 50% of Factor XII activity.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4.
Storage Instruction
Store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — F12
Entrez GeneID
2161Gene Name
F12
Gene Alias
HAE3, HAEX, HAF
Gene Description
coagulation factor XII (Hageman factor)
Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq
Other Designations
Hageman factor|coagulation factor XII
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