Mouse monoclonal antibody raised against native ITGA2.
Native purified ITGA2 from isolated human platelets.
The molecular weight of the recognized antigen is 138/115KDa under non-reducing conditions and 145/126KDa under reduced conditions. Recognizes the VLA2 antigen (alpha 2 beta 1 complex) also called Ia/IIa glycoprotein complex or collagen receptor. This antibody reacts with the molecules carrying the Br(a) as well as the Br(b) alloantigen. It reacts with platelets, megakaryocytes and activated T cells. Does not react with B lymphocytes, T lymphocytes, monocytes, granulocytes and red blood cells. This antibody inhibits the adhesion of platelets to collagen.
The optimal working dilution should be determined by the end user.
Lyophilized from PBS (1mg/mL BSA)
Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. [provided by RefSeq
integrin alpha 2,platelet antigen Br,platelet glycoprotein GPIa,platelet glycoprotein Ia,very late activation protein 2 receptor, alpha-2 subunit