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Last updated: 2017/10/15
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CTLA4 monoclonal antibody, clone BNI3

  • Catalog # : MAB4658
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant CTLA4.
  • Immunogen:
  • Recombinant protein corresponding to human CTLA4.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes CD152 (CTAL-4). The "cytolytic T-lymphocyte-associated antigen 4" (CTLA-4) is a member of the Ig superfamily (1) and its extracellular domain exhibits a single Ig V-like region. It was originally identified as a fourth cDNA product, during a search for genes that were thought to be specifically expressed in cytotoxic T lymphocytes (1). CTLA-4 has a molecular weight close to 45KDa (2). It is mainly expressed as a monomer (4), but may also be expressed as a disulfide-linked homodimer (2,3). CTLA-4 belongs to the CD28 receptor family (4,5).
  • Form:
  • Lyophilized
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Immunofluorescence (2ug/5x105 cells)
    Flow Cytometry (2ug/5x105 cells/test)
    Immunohistochemistry (Frozen sections)(5-50 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS (1mg/mL BSA)
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 1493
  • Gene Name:
  • CTLA4
  • Gene Alias:
  • CD152,CELIAC3,CTLA-4,GSE,IDDM12
  • Gene Description:
  • cytotoxic T-lymphocyte-associated protein 4
  • Gene Summary:
  • This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000163781,cytotoxic T-lymphocyte-associated antigen 4,cytotoxic T-lymphocyte-associated serine esterase-4,ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
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