ITGB2 monoclonal antibody, clone MEM-48 (PE)
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More Files
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Flow Cytometry
Surface staining of human peripheral blood cells with ITGB2 monoclonal antibody, clone MEM-48 (PE) (Cat # MAB4599).
Cells in the granulocyte gate were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB2.
Immunogen
Native purified ITGB2 from leukocytes of patient suffering from LGL-type leukaemia.
Host
Mouse
Reactivity
Human
Specificity
This antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin b2 subunit; b2 integrin). CD18 is a 90-95 KDa type I transmembrane protein expressed on all leukocytes.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human peripheral blood cells with ITGB2 monoclonal antibody, clone MEM-48 (PE) (Cat # MAB4599).
Cells in the granulocyte gate were used for analysis. -
Gene Info — ITGB2
Entrez GeneID
3689Gene Name
ITGB2
Gene Alias
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Gene Description
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
CD18 subunit|OTTHUMP00000115278|OTTHUMP00000115279|OTTHUMP00000115281|OTTHUMP00000115282|beta 2 integrin subunit|cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta 2|integrin bet
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Interactome
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Pathway
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Disease
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Publication Reference
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Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects.
Dassanayake RP, Maheswaran SK, Srikumaran S.
Infection and Immunity 2007 Aug; 75(10):5004.
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Association of the CD59 and CD55 cell surface glycoproteins with other membrane molecules.
Stefanová I, Horejsí V.
Journal of immunology 1991 Sep; 147(5):1587.
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Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein.
Bazil V, Stefanová I, Hilgert I, Kristofová H, Vanĕk S, Horejsí V.
Folia Biol (Praha) 1990 Jan; 36(1):41.
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Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects.
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