ITGAL monoclonal antibody, clone MEM-25 (PE)
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Flow Cytometry
Surface staining of human peripheral blood cells with ITGAL monoclonal antibody, clone MEM-25 (PE) (Cat # MAB4570).
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGAL.
Immunogen
Native purified ITGAL from leukocytes of patient suffering from LGL-type leukaemia.
Host
Mouse
Theoretical MW (kDa)
170-180
Reactivity
Human
Specificity
This antibody reacts with CD11a (alpha-subunit of human LFA-1), a 170-180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human peripheral blood cells with ITGAL monoclonal antibody, clone MEM-25 (PE) (Cat # MAB4570). -
Gene Info — ITGAL
Entrez GeneID
3683Gene Name
ITGAL
Gene Alias
CD11A, LFA-1, LFA1A
Gene Description
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Omim ID
153370Gene Ontology
HyperlinkGene Summary
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
LFA-1 alpha|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin alpha L|integrin gene promoter|lymphocyte function-associated antigen 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity.
Fujii T, Takada-Takatori Y, Kawashima K.
Life Sciences 2007 Jan; 80(24-25):2320.
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Membrane-proximal signaling events in beta-2 integrin activation.
Kellersch B, Kolanus W.
Results and Problems in Cell Differentiation 2006 Jan; 43:245.
Application：Flow Cyt, Human, Human hematopoietic cells, Human T cells.
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Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein.
Bazil V, Stefanová I, Hilgert I, Kristofová H, Vanĕk S, Horejsí V.
Folia Biol (Praha) 1990 Jan; 36(1):41.
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Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity.
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