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Last updated: 2016/12/4
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ITGAL monoclonal antibody, clone MEM-25 (PE)

  • Catalog # : MAB4570
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGAL.
  • Immunogen:
  • Native purified ITGAL from leukocytes of patient suffering from LGL-type leukaemia.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 170-180
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with CD11a (alpha-subunit of human LFA-1), a 170-180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.2% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • Surface staining of human peripheral blood cells with ITGAL monoclonal antibody, clone MEM-25 (PE) (Cat # MAB4570).
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 3683
  • Gene Name:
  • ITGAL
  • Gene Alias:
  • CD11A,LFA-1,LFA1A
  • Gene Description:
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
  • Gene Summary:
  • ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • LFA-1 alpha,antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide,integrin alpha L,integrin gene promoter,lymphocyte function-associated antigen 1
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