CD9 monoclonal antibody, clone MEM-61 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD9.
Immunogen
Native purified CD9 from Pre-B cell line NALM-6.
Host
Mouse
Theoretical MW (kDa)
24
Reactivity
Human
Specificity
This antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 KDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of NALM-6 (human pre-B cell leukemia cell line) with CD9 monoclonal antibody, clone MEM-61 (FITC) (Cat # MAB4566). Total viable cells were used for analysis. -
Gene Info — CD9
Entrez GeneID
928Gene Name
CD9
Gene Alias
5H9, BA2, BTCC-1, DRAP-27, GIG2, MIC3, MRP-1, P24, TSPAN29
Gene Description
CD9 molecule
Omim ID
143030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance. [provided by RefSeq
Other Designations
5H9 antigen|CD9 antigen|CD9 antigen (p24)|OTTHUMP00000041574|OTTHUMP00000041576|antigen defined by monoclonal antibody 602-29|growth-inhibiting gene 2 protein|leukocyte antigen MIC3|motility related protein|motility related protein-1|p24 antigen
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Publication Reference
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Platelet tetraspanin complexes and their association with lipid rafts.
Israels SJ, McMillan-Ward EM.
Thrombosis and Haemostasis 2007 Nov; 98(5):1081.
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Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells.
Kim YJ, Yu JM, Joo HJ, Kim HK, Cho HH, Bae YC, Jung JS.
Pflugers Archiv: European Journal of Physiology 2007 Aug; 455(2):283.
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The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.
Unternaehrer JJ, Chow A, Pypaert M, Inaba K, Mellman I.
PNAS 2006 Dec; 104(1):234.
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Platelet tetraspanin complexes and their association with lipid rafts.
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