ITGAM monoclonal antibody, clone MEM-174 (PE)
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Specifications
Product Description
Mouse monoclonal antibody raised against native ITGAM.
Immunogen
Native purified ITGAM from human granulocytes.
Host
Mouse
Theoretical MW (kDa)
165-170
Reactivity
Human
Specificity
This antibody recognizes CD11b antigen (Mac-1 alpha), a 165-170 KDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
Form
Liquid
Conjugation
PE
Isotype
IgG2a
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — ITGAM
Entrez GeneID
3684Gene Name
ITGAM
Gene Alias
CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6
Gene Description
integrin, alpha M (complement component 3 receptor 3 subunit)
Omim ID
120980Gene Ontology
HyperlinkGene Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen CD11b (p170)|complement component receptor 3, alpha|integrin alpha M|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Effects of beta-glucans on the immune system.
Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E.
Medicina (Kaunas, Lithuania) 2007 Aug; 43(8):597.
Application:Filow Cyt, Mouse, NK cells, Phagocytic cells.
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CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization.
Lawrence PK, Srikumaran S.
Veterinary Immunology and Immunopathology 2007 Oct; 119(3-4):287.
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Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI.
Blood 2000 Feb; 95(3):911.
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Effects of beta-glucans on the immune system.
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