SPN monoclonal antibody, clone MEM-59 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native SPN.
Immunogen
Native purified SPN from human T lymphocytes.
Host
Mouse
Theoretical MW (kDa)
95-135
Reactivity
Human
Specificity
This antibody recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 KDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation.
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — SPN
Entrez GeneID
6693Gene Name
SPN
Gene Alias
CD43, GPL115, LSN
Gene Description
sialophorin
Omim ID
182160Gene Ontology
HyperlinkGene Summary
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[supplied by OMIM
Other Designations
leukosialin|sialophorin (gpL115, leukosialin, CD43)|sialophorin (leukosialin, CD43)
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Interactome
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Pathway
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Disease
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Publication Reference
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Simova S, Klima M, Cermak L, Sourkova V, Andera L.
Apoptosis 2008 Mar; 13(3):423.
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MEM-59 monoclonal antibody detects a CD43 epitope involved in lymphocyte activation.
Alvarado M, Klassen C, Cerny J, Horejsí V, Schmidt RE.
European Journal of Immunology 1995 Apr; 25(4):1051.
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Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.
Cermak L, Simova S, Pintzas A, Horejsi V, Andera L.
The Journal of Biological Chemistry 2001 Dec; 277(10):7955.
Application:Flow Cyt, Human, TF-1 cells.
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Characterization of a 95 kDa human leucocyte sialoglycoprotein: its identity with CD43, gpL115, leukosialin and sialophorin.
Stefanová I, Hilgert I, Angelisová P, Kristofová H, Horejsí V.
Folia Biol (Praha) 1988 Jan; 34(4):255.
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
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