CD6 monoclonal antibody, clone MEM-98 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD6.
Immunogen
Native purified human CD6.
Host
Mouse
Theoretical MW (kDa)
100-130
Reactivity
Human
Specificity
The antibody reacts with CD6, a 100-130 kD single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD6
Entrez GeneID
923Gene Name
CD6
Gene Alias
FLJ44171, TP120
Gene Description
CD6 molecule
Omim ID
186720Gene Ontology
HyperlinkGene Summary
CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation (Robinson et al., 1995 [PubMed 7589069]).[supplied by OMIM
Other Designations
CD6 antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
Zimmerman AW, Joosten B, Torensma R, Parnes JR, van Leeuwen FN, Figdor CG.
Blood 2005 Dec; 107(8):3212.
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CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM.
Osorio LM, De Santiago A, Aguilar-Santelises M, Mellstedt H, Jondal M.
Blood 1997 Apr; 89(8):2833.
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Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
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