CD7 monoclonal antibody, clone MEM-186 (FITC)
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More Files
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Flow Cytometry
Surface staining of human peripheral blood cells with CD7 monoclonal antibody, clone MEM-186 (FITC) (Cat # MAB4540).
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Specification
Product Description
Mouse monoclonal antibody raised against native CD7.
Immunogen
Native purified CD7 from human acute myelogenous leukaemia cell line KG-1.
Host
Mouse
Theoretical MW (kDa)
40
Reactivity
Human
Specificity
The antibody reacts with CD7, a 40 KDa type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.
Form
Liquid
Conjugation
FITC
Isotype
IgG
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human peripheral blood cells with CD7 monoclonal antibody, clone MEM-186 (FITC) (Cat # MAB4540). -
Gene Info — CD7
Entrez GeneID
924Gene Name
CD7
Gene Alias
GP40, LEU-9, TP41, Tp40
Gene Description
CD7 molecule
Omim ID
186820Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq
Other Designations
CD7 antigen|CD7 antigen (p41)|T-cell antigen CD7|T-cell leukemia antigen|p41 protein
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Interactome
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Pathway
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Publication Reference
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Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M.
Nishimura M, Takanashi M, Okazaki H, Satake M, Nakajima K.
Endothelium 2006 Jul; 13(4):287.
Application：Flow Cyt, Func, Human, LME cells.
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CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotype.
Chang H, Yeung J, Brandwein J, Yi QL.
Leukemia Research 2006 Jul; 31(2):157.
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Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma.
Lam GK, Liao HX, Xue Y, Alam SM, Scearce RM, Kaufman RE, Sempowski GD, Haynes BF.
Journal of Clinical Immunology 2005 Jan; 25(1):41.
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Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M.
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