FUT4 monoclonal antibody, clone MEM-158 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native FUT4.
Immunogen
Native purified FUT4 from human granulocytes.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.
Form
Liquid
Conjugation
Biotin
Concentration
1 mg/mL
Isotype
IgM
Recommend Usage
Flow Cytometry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — FUT4
Entrez GeneID
2526Gene Name
FUT4
Gene Alias
CD15, ELFT, FCT3A, FUC-TIV, FUTIV
Gene Description
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Omim ID
104230Gene Ontology
HyperlinkGene Summary
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq
Other Designations
ELAM ligand fucosyltransferase|fucosyltransferase 4|fucosyltransferase IV|galactoside 3-L-fucosyltransferase
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Interactome
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Pathway
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Publication Reference
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Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).
Li C, Wong P, Pan T, Xiao F, Yin S, Chang B, Kang SC, Ironside J, Sy MS.
The Biochemical Journal 2007 Sep; 406(2):333.
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Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease.
Benharroch D, Dima E, Levy A, Ohana-Malka O, Ariad S, Prinsloo I, Mejirovsky E, Sacks M, Gopas J.
Leukemia & Lymphoma 2000 Sep; 39(1-2):185.
Application：IHC-P, Human, Hodgkin-reed-sternberg cells in tumors from patients with Hodgkin's disease.
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Le(X) and related structures as adhesion molecules.
Hakomori S.
The Histochemical Journal 1992 Nov; 24(11):771.
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Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).
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